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MEDIUMResearchTier 1

Teriparatide topical delivery supports osseointegration in ovariectomized rats receiving

SourceClinical Oral Implants ResearchTier 1Peer-Reviewed Research

By Ana Cláudia Ervolino da Silva, Fábio Roberto de Souza Batista, Jaqueline Suemi Hassumi, Naara Gabriela Monteiro, Marina Santos Fernandes, Luana Marotta Reis Vasconcellos, Gabriel Mulinari‐Santos, Reinhard Gruber, Paulo Noronha Lisboa‐Filho, Roberta Okamoto

Originally at onlinelibrary.wiley.com

Summary & scoring by The Bell Brief (Dr. Jennifer Bell) using the Drill-Down Protocol (Drill-Down Score) — not the original publisher.

Why it matters for dental

Dental implant researchers may gain a new local-delivery option for improving osseointegration in patients with estrogen deficiency, cafeteria-style diet, and bisphosphonate use; owners and specialists should watch for human translation studies.

Key points

  • In vitro, titanium discs coated with 10 or 40 ng teriparatide each produced mineralized nodule formation and UV–Vis spectroscopy confirmed drug adsorption.
  • Researchers placed teriparatide-coated or uncoated titanium implants bilaterally in the maxillae of 48 rats assigned to SHAM, OVX/CD, or OVX/CD/RIS groups and euthanized them at 28 days.
  • Removal torque testing showed teriparatide significantly increased values across all groups, with the largest increase observed in the OVX/CD/RIS group.
  • Micro-CT and fluorescence microscopy revealed increased peri-implant bone volume in the OVX/CD and OVX/CD/RIS groups after teriparatide coating.

Who should care

SpecialistAcademia

Read the original on Clinical Oral Implants Research

Full reporting and any paywall content live on onlinelibrary.wiley.com. We summarize and score; we do not republish.

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