The osteoimmune cell atlas of peri-implantitis: a narrative scoping review
By Emilio A. Cafferata, Anton Sculean, Frank Schwarz
Originally at onlinelibrary.wiley.com
Summary & scoring by The Bell Brief (Dr. Jennifer Bell) using the Drill-Down Protocol (Drill-Down Score) — not the original publisher.
Why it matters for dental
Peri-implantitis research now outlines an immune-cell atlas that could guide future diagnostics and targeted therapies for implant failure; specialists and implant surgeons should track these pathways for emerging precision treatments.
Key points
- Scoping review integrates transcriptomics, single-cell RNA sequencing, spatial transcriptomics, flow cytometry, and immunohistochemistry data on peri-implantitis lesions.
- Evidence shows expanded and activated neutrophil, macrophage, T-cell, and B-lineage compartments plus stromal and vascular populations in peri-implantitis tissue.
- Reported immune features include CXCR2+ neutrophil subsets, inflammatory macrophage states, altered Th17/Treg responses, and organized B-cell/plasma-cell niches.
- Knowledge gaps remain for NLRP3 inflammasome activation, type I interferon signaling, cellular RANKL hierarchies, and functional data on rare immune populations.
Who should care
Read the original on Periodontology 2000
Full reporting and any paywall content live on onlinelibrary.wiley.com. We summarize and score; we do not republish.
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