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The Bell BriefFrom Dr. Jennifer Bell, DDS
HIGHResearchTier 1

Platelet‐rich plasma (PRP) versus injectable platelet‐rich fibrin (i‐PRF): A systematic review across all fields of medicine

SourcePeriodontology 2000Tier 1Peer-Reviewed Research

By Nima Farshidfar, Mohammad Amin Amiri, Nathan E. Estrin, Paras Ahmad, Anton Sculean, Yufeng Zhang, Richard J. Miron

Originally at onlinelibrary.wiley.com

Summary & scoring by The Bell Brief (Dr. Jennifer Bell) using the Drill-Down Protocol (Drill-Down Score) — not the original publisher.

Why it matters for dental

Practice owners and periodontists deciding between autologous blood concentrates now have the first head-to-head systematic review comparing PRP and i-PRF across medicine; the data can directly inform product selection, chair-side protocols, and fee schedules for periodontal regeneration, implant site development, and sinus augmentation.

Key points

  • Periodontology 2000, Oct 2025, 30-page systematic review synthesizes evidence from 58 RCTs across surgical specialties including oral surgery and periodontics.
  • i-PRF protocols require no anticoagulant or activator and can be prepared chair-side in <8 minutes, versus PRP’s 30–45 minute centrifuge-plus-activator workflow.
  • Meta-analysis shows i-PRF yields comparable or higher early growth-factor release (VEGF, PDGF-BB) and statistically lower patient-reported pain scores at 24 h post-op versus PRP.
  • Review flags inconsistent PRP dosing across trials and calls for standardization; practices relying on PRP should audit centrifuge settings and activation methods to reduce outcome variability.

Who should care

SpecialistAcademiaOwner

Read the original on Periodontology 2000

Full reporting and any paywall content live on onlinelibrary.wiley.com. We summarize and score; we do not republish.

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