Mapping the omics landscape for peri‐implant diseases: A scoping review
By Ethan Ng, Ioannis Fragkioudakis, Jeniffer Perussolo, John Rong Hao Tay, Elena Calciolari, Nikos Donos
Originally at onlinelibrary.wiley.com
Summary & scoring by The Bell Brief (Dr. Jennifer Bell) using the Drill-Down Protocol (Drill-Down Score) — not the original publisher.
Why it matters for dental
Periodontists and implant teams should expect future diagnostic panels that combine microbial, proteomic, and host-response markers to detect peri-implantitis earlier and more accurately than current clinical or radiographic criteria alone.
Key points
- The review systematically maps omics studies (metagenomics, transcriptomics, proteomics, metabolomics) that differentiate healthy peri-implant tissue from peri-implant mucositis and peri-implantitis.
- Host-derived inflammatory proteins and microbial shifts are consistently altered before crestal bone loss is visible on radiographs.
- No single biomarker or signature has yet reached clinical validation; most studies are small, cross-sectional, and lack standardized sampling protocols.
- Authors highlight the need for longitudinal, multi-center trials to develop chair-side omics diagnostics and targeted host-modulation therapies.
Who should care
Read the original on Periodontology 2000
Full reporting and any paywall content live on onlinelibrary.wiley.com. We summarize and score; we do not republish.
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