← Daily Brief
The Bell BriefFrom Dr. Jennifer Bell, DDS
HIGHResearchTier 1

Hyaluronic acid: A novel approach in regenerative/reconstructive periodontal therapy?

SourcePeriodontology 2000Tier 1Peer-Reviewed Research

By Andrea Pilloni, Yoshinori Shirakata, Lorenzo Marini, Darko Božić, Richard J. Miron, Roberto Rotundo, Andreas Stavropoulos, Anton Sculean

Originally at onlinelibrary.wiley.com

Summary & scoring by The Bell Brief (Dr. Jennifer Bell) using the Drill-Down Protocol (Drill-Down Score) — not the original publisher.

Why it matters for dental

Periodontists and general dentists who perform regenerative procedures should note that hyaluronic acid is emerging as a bioactive adjunct that may improve clinical attachment gain and reduce recession depth; early adoption could differentiate high-end perio practices and affect material budgets.

Key points

  • October 2025 special issue of Periodontology 2000 (Vol. 99) devotes 28 pages to HA’s biologic rationale and surgical protocols.
  • Systematic reviews cited show mean probing-depth reductions of 1.1–2.3 mm and attachment gains of 0.8–1.7 mm versus open-flap debridement alone.
  • HA carriers can be combined with xenografts, autografts, or enamel-matrix derivative, potentially lowering the volume of costly biologics required per site.
  • Current evidence is still largely from split-mouth RCTs (n ≤ 60) with 6–12 month follow-up; practices should budget for additional training and track outcomes until larger multicenter data appear.

Who should care

SpecialistAcademia

Read the original on Periodontology 2000

Full reporting and any paywall content live on onlinelibrary.wiley.com. We summarize and score; we do not republish.

Open original

Related