Effect of Intracanal Medications on Cell Adhesion, Viability, and Differentiation During Regenerative Endodontic Procedures: A Systematic Review of <em>In Vitro</em> Studies
Originally at sciencedirect.com
Summary & scoring by The Bell Brief (Dr. Jennifer Bell) using the Drill-Down Protocol (Drill-Down Score) — not the original publisher.
Why it matters for dental
This systematic review of in-vitro data shows that the intracanal medicaments commonly used in regenerative endodontics can measurably alter stem-cell adhesion, viability, and dentinogenic differentiation, directly affecting the success of pulp-revascularization procedures that endodontists and pediatric dentists now perform on immature teeth.
Key points
- Review analyzed 24 in-vitro studies on medicaments such as calcium hydroxide, triple antibiotic paste, and newer bioceramics.
- Findings indicate that triple antibiotic paste consistently reduced stem-cell viability and dentinogenic differentiation compared with calcium hydroxide or bioceramics.
- No single medicament demonstrated optimal cell adhesion, viability, and differentiation simultaneously, highlighting the need for material-specific protocols.
- Results provide endodontists and pediatric dentists with evidence-based guidance to adjust regenerative protocols and potentially improve long-term tooth survival.
Who should care
Read the original on Journal of Endodontics
Full reporting and any paywall content live on sciencedirect.com. We summarize and score; we do not republish.
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