Effect of collagen cross-linkers on the bonding performance of resin-dentin interfaces: A systematic review and meta-analysis of in vitro studies
Originally at sciencedirect.com
Summary & scoring by The Bell Brief (Dr. Jennifer Bell) using the Drill-Down Protocol (Drill-Down Score) — not the original publisher.
Why it matters for dental
Dentists who bond composite or indirect restorations to dentin can expect improved long-term bond durability if collagen cross-linkers become part of routine adhesive protocols; the meta-analysis quantifies how much these agents reduce micro-leakage and bond-strength loss.
Key points
- Systematic review pooled 22 in-vitro studies evaluating EDC, glutaraldehyde, riboflavin/UVA, and proanthocyanidin applied before or during bonding.
- Pooled data show a statistically significant increase in immediate microtensile bond strength (mean difference 9.8 MPa) and a 36 % reduction in nanoleakage scores versus controls.
- Cross-linkers were most effective in etch-and-rinse systems; self-etch adhesives showed smaller but still positive gains.
- No clinical trials are included; in-vitro findings still inform adhesive-material selection and future product development.
Who should care
Read the original on Journal of Prosthetic Dentistry (JPD)
Full reporting and any paywall content live on sciencedirect.com. We summarize and score; we do not republish.
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