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The Bell BriefFrom Dr. Jennifer Bell, DDS
HIGHResearchTier 1

Clinical, Radiographic and Patient‐Centred Outcomes of MINST Versus MIST With Enamel Matrix Derivative in Class II Mandibular Furcation Defects: A Randomised Controlled Trial

SourceJournal of Clinical PeriodontologyTier 1Peer-Reviewed Research

By Georgios S. Chatzopoulos, Eleftherios G. Kaklamanos, Ioannis Vouros, Georgios Mikrogeorgis, Aikaterini‐Elissavet Doufexi, Lazaros Tsalikis

Originally at onlinelibrary.wiley.com

Summary & scoring by The Bell Brief (Dr. Jennifer Bell) using the Drill-Down Protocol (Drill-Down Score) — not the original publisher.

Why it matters for dental

Periodontists and general dentists performing periodontal surgery now have RCT-level evidence comparing two minimally invasive regenerative techniques for mandibular Class II furcations—information that can shift treatment planning and informed-consent discussions.

Key points

  • The trial directly compares minimally invasive non-surgical therapy (MINST) versus minimally invasive surgical therapy (MIST) plus enamel matrix derivative in mandibular Class II furcations.
  • Primary outcomes include clinical attachment level gain, radiographic bone fill, and patient-reported outcome measures at 12 months.
  • Findings are published in the September 2026 issue of the Journal of Clinical Periodontology (Volume 53, Issue 9, pp. 1413-1422).
  • Clinicians treating furcation-involved molars can use these data to decide whether a non-surgical or flap-based regenerative approach offers superior hard-tissue and patient-centered results.

Who should care

SpecialistAcademia

Read the original on Journal of Clinical Periodontology

Full reporting and any paywall content live on onlinelibrary.wiley.com. We summarize and score; we do not republish.

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