Clinical efficacy of platelet-rich fibrin therapy during oral surgical interventions
By Fawad Javed, Muhammad Saad Shaikh, Anton Sculean, Richard J. Miron
Originally at onlinelibrary.wiley.com
Summary & scoring by The Bell Brief (Dr. Jennifer Bell) using the Drill-Down Protocol (Drill-Down Score) — not the original publisher.
Why it matters for dental
Oral surgeons and periodontists may see improved post-extraction healing in cigarette smokers when PRF is added, but the evidence is too limited and heterogeneous to change protocols or billing.
Key points
- Three randomized controlled trials with 18–102 participants each tested adjunctive PRF versus non-PRF controls in cigarette smokers undergoing oral surgical interventions.
- One trial reported 6-month radiographic and histologic outcomes after socket preservation plus short-term soft-tissue healing and pain scores.
- Two trials performed sample-size calculations; one included trial carried a high risk of bias while the others raised some concerns.
- GRADE certainty ratings for the reported outcomes ranged from very low to moderate.
Who should care
Read the original on Periodontology 2000
Full reporting and any paywall content live on onlinelibrary.wiley.com. We summarize and score; we do not republish.
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