HIGHClinicalTier 1
Twenty‐Five‐Year Follow‐Up of Individuals With Intact Periodontium and Differing Susceptibility to Experimentally Induced Gingival Inflammation
SourceJournal of Clinical PeriodontologyTier 1Peer-Reviewed Research
By Leonardo Trombelli, Jenny Guidorzi, Dimitris N. Tatakis, Roberto Farina
Originally at onlinelibrary.wiley.com
Summary & scoring by The Bell Brief (Dr. Jennifer Bell) using the Drill-Down Protocol (Drill-Down Score) — not the original publisher.
Why it matters for dental
Long-term cohort data now show that some patients with pristine periodontium still develop rapid gingival inflammation under identical plaque challenge, giving clinicians a measurable way to predict risk and intensify preventive protocols before attachment loss begins.
Key points
- 25-year follow-up of 113 adults originally free of periodontitis; 18 % were classified 'high responders' to experimental gingivitis despite identical plaque levels.
- High-responder status at baseline predicted 2.7-fold higher odds of future periodontitis progression over 25 years (p<0.01).
- No difference in plaque index or bleeding on probing scores between groups at day 21 of experimental gingivitis, but high responders showed earlier IL-1β and IL-6 spikes.
- Authors propose a simple 21-day experimental gingivitis test in young adults to stratify prevention intensity, especially in high-caries or ortho populations.
Who should care
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Read the original on Journal of Clinical Periodontology
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